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OIn December 2021, IVI and the University of Antananarivo opened the Madagascar Institute for Vaccine Research, also known as the “the University of Antananarivo – International Vaccine Institute Collaborating Center” with a ceremony held at the University of Antananarivo.

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ABOUT SETA PLUS

What is the SETA PLUS Program?

About SETA PLUS

The Severe Typhoid in Africa (SETA) Plus Program is an expansion of the original SETA initiative, which investigates the burden of typhoid fever and other invasive Salmonella infections in sub-Saharan Africa. With additional funding of $4.33 million from the Bill & Melinda Gates Foundation, SETA Plus aims to provide critical data to inform vaccination policies and support the introduction of typhoid conjugate vaccines in Africa.

Why is SETA Plus Important?

Typhoid fever is a major public health issue in both Asia and Africa, but there is limited understanding of its severe health complications and socio-economic impacts, especially in Africa. SETA Plus seeks to bridge this knowledge gap by:

Gathering high-quality, standardized data on typhoid burden and related diseases.


Evaluating the effectiveness of vaccination programs.


Strengthening global efforts to combat drug-resistant Salmonella infections.

Key Studies and Objectives

  • 1. Continuing data collection in five African countries: Ghana, the Democratic Republic of the Congo, Nigeria, Madagascar, and Burkina Faso.
  • 2. Monitoring invasive Salmonella infections, severe manifestations of illness, and the economic burden of typhoid.

Generating evidence to guide governments in adopting Gavi-supported typhoid conjugate vaccine (TCV)programs.

Leveraging data from the Typhoid Fever Surveillance in Africa Program (TSAP) and the original SETA study to evaluate disease burden and prevalence of drug-resistant strains.

Collaboration and Alignment with Global Efforts

SETA Plus works in close coordination with related programs like:

  • 1. THECA (Effect of a novel typhoid conjugate vaccine in Africa): A multi-center study in Ghana and the Democratic Republic of the Congo, coordinated by the University of Cambridge.
  • 2. Typhoid Vaccine Acceleration Consortium (TyVAC): A partnership led by the Center for Vaccine Development at the University of Maryland, the Oxford Vaccine Group, and PATH.

Funding and Impact

The Bill & Melinda Gates Foundation has invested a total of $13.86 million in SETA-related programs, recognizing the value of understanding the epidemiological and economic burden of typhoid.

The Goal

By generating actionable data on the burden of typhoid and the impact of vaccination, SETA Plus supports efforts to reduce the disease's prevalence and improve health outcomes across sub-Saharan Africa. This work complements global initiatives for typhoid control, ensuring that vulnerable populations have access to life-saving vaccines and treatments.